Kininogen 1 Rabbit pAb

• Background :

  Kininogens are inhibitors of thiol proteases; HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes; LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids. UCHL1 is abundantly expressed in neuronal tissues and testes.

• Description :

  Kininogens are inhibitors of thiol proteases;  HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes;  the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects. LMW-kininogen inhibits the aggregation of thrombocytes;  LMW-kininogen is in contrast to HMW-kininogen not involved in blood clottingUCHL1, UCHL3, UCHL5/UCH37, and BRCA-1-associated protein-1 (BAP1) belong to the UCH family of DUBs, which all posses a conserved catalytic domain (UCH domain) of about 230 amino acids.   UCHL1 is abundantly expressed in neuronal tissues and testes.

• Product Name Alternative :

  BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1

• UniProt :

  P01042

• Swiss Prot :

  P01042

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant Protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB, IHC

• Concentration :

  1mg/mL

• Dilution :

  WB 1:1500-1,000 IHC 1:100-200

• Buffer :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Molecular Weight :

  45-120kDa

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight :

  45-120kDa

• Fragment :

  IgG

• Subcellular Location :

  Secreted

• Other Product Names :

  BDK, Fitzgerald factor, HMWK, Ile Ser Bradykinin Bradykinin, Kallidin I Lysyl bradykinin, kininogen 1, KNG, KNG1

• Gene ID (Human) :

  3827