Syk (phospho Tyr348) rabbit pAb

• Background :

  This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

• Description :

  This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],

• UniProt :

  P43405

• Swiss Prot :

  P43405

• Reactivity :

  Human; Mouse; Rat; Monkey

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SYK around the phosphorylation site of Tyr348. AA range:314-363

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  72kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  72kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane . Cytoplasm, cytosol .

• Other Product Names :

  SYK; Tyrosine-protein kinase SYK; Spleen tyrosine kinase; p72-Syk

• Gene ID (Human) :

  6850