BAM32 rabbit pAb

• Background :

  Function:May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR) -signaling downstream of PI3K., induction:Upon B-cell activation., PTM:Phosphorylated on tyrosine residues., similarity:Contains 1 PH domain., similarity:Contains 1 SH2 domain., subcellular location:Membrane-associated after cell stimulation leading to its translocation., subunit:Interacts with PtdIns (3,4,5) P3 and PLCG2. In vitro, interacts with PtdIns (3,4) P2., tissue specificity:Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

• Description :

  Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K. induction: Upon B-cell activation. PTM: Phosphorylated on tyrosine residues. similarity: Contains 1 PH domain. similarity: Contains 1 SH2 domain. subcellular location: Membrane-associated after cell stimulation leading to its translocation. subunit: Interacts with PtdIns (3, 4, 5)P3 and PLCG2. In vitro, interacts with PtdIns (3, 4)P2. tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

• UniProt :

  Q9UN19

• Swiss Prot :

  Q9UN19

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human DAPP1. AA range:105-154

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  32kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  32kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Membrane ; Peripheral membrane protein . Membrane-associated after cell stimulation leading to its translocation.

• Other Product Names :

  DAPP1; BAM32; HSPC066; Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; hDAPP1; B lymphocyte adapter protein Bam32; B-cell adapter molecule of 32 kDa

• Gene ID (Human) :

  27071