Claudin-19 rabbit pAb

• Background :

  The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO) . HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]

• Description :

  The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010],

• Product Name Alternative :

  CLDN19; Claudin-19

• UniProt :

  Q8N6F1

• Swiss Prot :

  Q8N6F1

• Reactivity :

  Human; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human CLDN19. AA range:81-130

• Target :

  Claudin-19

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  23kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  23kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

• Other Product Names :

  CLDN19; Claudin-19

• Gene ID (Human) :

  149461