Ikaros 3 rabbit pAb

• Background :

  This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

• Description :

  This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012],

• Product Name Alternative :

  IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3

• UniProt :

  Q9UKT9

• Swiss Prot :

  Q9UKT9

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human IKZF3. AA range:361-410

• Target :

  Ikaros 3

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  62kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  62kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm .; [Isoform 1]: Nucleus .; [Isoform 3]: Nucleus .; [Isoform 11]: Nucleus .; [Isoform 14]: Nucleus . Cytoplasm .; [Isoform 12]: Cytoplasm .

• Other Product Names :

  IKZF3; ZNFN1A3; Zinc finger protein Aiolos; Ikaros family zinc finger protein 3

• Gene ID (Human) :

  22806