MAST205 rabbit pAb

• Background :

  Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., function:Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation., PTM:Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 PDZ (DHR) domain., similarity:Contains 1 protein kinase domain., subcellular location:Recruited to the sub-membranous area on interaction with PC-LKC., tissue specificity:Abundant in the testis.

• Description :

  Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. PTM: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 protein kinase domain. subcellular location: Recruited to the sub-membranous area on interaction with PC-LKC. tissue specificity: Abundant in the testis.

• Product Name Alternative :

  MAST2; KIAA0807; MAST205; Microtubule-associated serine/threonine-protein kinase 2

• UniProt :

  Q6P0Q8

• Swiss Prot :

  Q6P0Q8

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human MAST2. AA range:1201-1250

• Target :

  MAST205

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  196kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  196kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytoskeleton . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Recruited to the sub-membranous area on interaction with CDHR2.

• Other Product Names :

  MAST2; KIAA0807; MAST205; Microtubule-associated serine/threonine-protein kinase 2

• Gene ID (Human) :

  23139