MyD88 rabbit pAb

• Background :

  This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

• Description :

  This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

• UniProt :

  Q99836

• Swiss Prot :

  Q99836

• Reactivity :

  Human; Mouse; Rat; Pig

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human MyD88. AA range:171-220

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IF; WB; IHC; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunocytochemistry: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  33kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  33kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus .

• Other Product Names :

  MYD88; Myeloid differentiation primary response protein MyD88

• Gene ID (Human) :

  4615