SIRT1 rabbit pAb

• Background :

  This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

• Description :

  This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008],

• UniProt :

  Q96EB6

• Swiss Prot :

  Q96EB6

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SirT1. AA range:13-62

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IF; WB; IHC; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight :

  85-110kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  85-110kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, PML body . Cytoplasm . Nucleus . Recruited to the nuclear bodies via its interaction with PML (PubMed:12006491) . Colocalized with APEX1 in the nucleus (PubMed:19934257) . May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane (PubMed:15469825) . Shuttles between nucleus and cytoplasm (By similarity) . Colocalizes in the nucleus with XBP1 isoform 2 (PubMed:20955178) . .; [SirtT1 75 kDa fragment]: Cytoplasm . Mitochondrion .

• Other Product Names :

  SIRT1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; Regulatory protein SIR2 homolog 1; SIR2-like protein 1; hSIR2

• Gene ID (Human) :

  23411