C/EBP α (phospho Thr230) rabbit pAb

• Background :

  This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]

• Description :

  This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],

• Product Name Alternative :

  CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha

• UniProt :

  P49715

• Swiss Prot :

  P49715

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized phospho-peptide around the phosphorylation site of human C/EBP α (phospho Thr230)

• Target :

  C/EBP α

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  42,also have 30kd isform

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  42, also have 30kd isform

• Fragment :

  IgG

• Subcellular Location :

  Nucleus .; [Isoform 4]: Nucleus, nucleolus .

• Other Product Names :

  CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha

• Gene ID (Human) :

  1050