Rab11-FIP2 rabbit pAb

• Background :

  Function:A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) ., similarity:Contains 1 C2 domain., subcellular location:Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane., subunit:Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding.

• Description :

  Function: A Rab11 effector protein acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Binds preferentially to phosphatidylinositol 3, 4, 5-trisphosphate (PtdInsP3) and phosphatidic acid (PA). similarity: Contains 1 C2 domain. subcellular location: Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. subunit: Homooligomerizes in a Rab11-independent manner. Forms an heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB11A, RAB11B, RAB25 and REPS1. Interacts with RAB11A/RAB11B that has been activated by GTP binding.

• Product Name Alternative :

  RAB11FIP2; KIAA0941; Rab11 family-interacting protein 2; Rab11-FIP2; NRip11

• UniProt :

  Q7L804

• Swiss Prot :

  Q7L804

• Reactivity :

  Human; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human RAB11FIP2. AA range:340-389

• Target :

  Rab11-FIP2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  58kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  58kD

• Fragment :

  IgG

• Subcellular Location :

  Cell projection, phagocytic cup . Cell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane.

• Other Product Names :

  RAB11FIP2; KIAA0941; Rab11 family-interacting protein 2; Rab11-FIP2; NRip11

• Gene ID (Human) :

  22841