JMJD2B rabbit pAb

• Background :

  Cofactor:Binds 1 Fe (2+) ion per subunit., domain:The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate., similarity:Belongs to the JHDM3 histone demethylase family., similarity:Contains 1 JmjC domain., similarity:Contains 1 JmjN domain., similarity:Contains 2 PHD-type zinc fingers., similarity:Contains 2 Tudor domains.

• Description :

  Cofactor: Binds 1 Fe (2+) ion per subunit. Domain: The 2 Tudor domains recognize and bind methylated histones. Double Tudor domain has an interdigitated structure and the unusual fold is required for its ability to bind methylated histone tails. function: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. similarity: Belongs to the JHDM3 histone demethylase family. similarity: Contains 1 JmjC domain. similarity: Contains 1 JmjN domain. similarity: Contains 2 PHD-type zinc fingers. similarity: Contains 2 Tudor domains.

• UniProt :

  O94953

• Swiss Prot :

  O94953

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human KDM4B. AA range:351-400

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Nucleus .

• Other Product Names :

  KDM4B; JHDM3B; JMJD2B; KIAA0876; Lysine-specific demethylase 4B; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B

• Gene ID (Human) :

  23030