GCKR rabbit pAb

• Background :

  This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY) . [provided by RefSeq, Jul 2008]

• Description :

  This gene encodes a protein belonging to the GCKR subfamily of the SIS (Sugar ISomerase) family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY). [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  GCKR; Glucokinase regulatory protein; Glucokinase regulator

• UniProt :

  Q14397

• Swiss Prot :

  Q14397

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human Glucokinase Regulator. AA range:211-260

• Target :

  GCKR

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  68kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  68kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Mitochondrion . Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. .

• Other Product Names :

  GCKR; Glucokinase regulatory protein; Glucokinase regulator

• Gene ID (Human) :

  2646