Dynein IC1 rabbit pAb

• Background :

  This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

• Description :

  This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

• Product Name Alternative :

  DNAI1; Dynein intermediate chain 1; axonemal; Axonemal dynein intermediate chain 1

• UniProt :

  Q9UI46

• Swiss Prot :

  Q9UI46

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human DNAI1. AA range:211-260

• Target :

  Dynein IC1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  79kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  79kD

• Fragment :

  IgG

• Subcellular Location :

  Dynein axonemal particle . Cytoplasm, cytoskeleton, cilium axoneme .

• Other Product Names :

  DNAI1; Dynein intermediate chain 1; axonemal; Axonemal dynein intermediate chain 1

• Gene ID (Human) :

  27019