IGF-IR (phospho Tyr1346) rabbit pAb

• Background :

  This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

• Description :

  This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

• UniProt :

  P08069

• Swiss Prot :

  P08069

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human IGF1R around the phosphorylation site of Tyr1346. AA range:1311-1360

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  pro: 155kD, recetor beta: 95kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  Pro: 155kD, recetor beta: 95kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein .

• Other Product Names :

  IGF1R; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD antigen CD221

• Gene ID (Human) :

  3480