Na+/K+-ATPase α2 rabbit pAb

• Background :

  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta) . The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008]

• Description :

  The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. [provided by RefSeq, Oct 2008],

• Product Name Alternative :

  ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na (+) /K (+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

• UniProt :

  P50993

• Swiss Prot :

  P50993

• Reactivity :

  Human; Mouse; Rat; Monkey

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human ATP1A2. AA range:971-1020

• Target :

  Na+/K+-ATPase α2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  112kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  112kD

• Fragment :

  IgG

• Subcellular Location :

  Membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein .

• Other Product Names :

  ATP1A2; KIAA0778; Sodium/potassium-transporting ATPase subunit alpha-2; Na (+) /K (+) ATPase alpha-2 subunit; Sodium pump subunit alpha-2

• Gene ID (Human) :

  477