DNA pol δ cat rabbit pAb

• Background :

  This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]

• Description :

  This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012],

• Product Name Alternative :

  POLD1; POLD; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125

• UniProt :

  P28340

• Swiss Prot :

  P28340

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human POLD1. AA range:1051-1100

• Target :

  DNA pol δ cat

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  110 124kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  110 124kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Colocalizes with PCNA and POLD3 at S phase replication sites (PubMed:11595739) . After UV irradiation, recruited to DNA damage sites within 2 hours, independently on the cell cycle phase, nor on PCNA ubiquitination. This recruitment requires POLD3, PCNA and RFC1-replication factor C complex (PubMed:20227374, PubMed:22801543) . .

• Other Product Names :

  POLD1; POLD; DNA polymerase delta catalytic subunit; DNA polymerase subunit delta p125

• Gene ID (Human) :

  5424