SNAT2 rabbit pAb

• Background :

  Enzyme regulation:Inhibited by N-methyl-D-glucamine and probably choline., function:Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta., induction:Up-regulated upon hypertonic conditions and amino acid deprivation., miscellaneous:Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress., PTM:Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2., similarity:Belongs to the amino acid/polyamine transporter 2 family., subcellular location:Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal., tissue specificity:Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level) .

• Description :

  Enzyme regulation: Inhibited by N-methyl-D-glucamine and probably choline. function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1: 1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. induction: Up-regulated upon hypertonic conditions and amino acid deprivation. miscellaneous: Depletion of SCL38A2 by siRNA prevents the recovery of cells from hypertonic stress. PTM: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. similarity: Belongs to the amino acid/polyamine transporter 2 family. subcellular location: Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. tissue specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level).

• Product Name Alternative :

  SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a

• UniProt :

  Q96QD8

• Swiss Prot :

  Q96QD8

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SLC38A2. AA range:151-200

• Target :

  SNAT2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  50kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  50kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Multi-pass membrane protein . Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (By similarity) . Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. .

• Other Product Names :

  SLC38A2; ATA2; KIAA1382; SAT2; SNAT2; Sodium-coupled neutral amino acid transporter 2; Amino acid transporter A2; Protein 40-9-1; Solute carrier family 38 member 2; System A amino acid transporter 2; System A transporter 1; System N amino a

• Gene ID (Human) :

  54407