β-1,4-GalNAc-T rabbit pAb

• Background :

  Catalytic activity:UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl- (1->3) -D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl- (1->4) -beta-D-glucuronyl- (1->3) -beta-D-galactosylproteoglycan., function:Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA) . Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage., online information:Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1, online information:GlycoGene database, PTM:N-glycosylated., similarity:Belongs to the chondroitin N-acetylgalactosaminyltransferase family., tissue specificity:Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

• Description :

  Catalytic activity: UDP-N-acetyl-D-galactosamine + beta-D-glucuronyl- (1->3)-D-galactosyl-proteoglycan = UDP + N-acetyl-D-galactosaminyl- (1->4)-beta-D-glucuronyl- (1->3)-beta-D-galactosylproteoglycan. function: Transfers 1, 4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage. online information: Chondroitin beta-1, 4-N-acetylgalactosaminyltransferase 1, online information: GlycoGene database, PTM: N-glycosylated. similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family. tissue specificity: Ubiquitous, with the highest levels in placenta, thyroid, bladder, prostate and adrenal gland. Detected at low levels in the other tissues examined.

• UniProt :

  Q8TDX6

• Swiss Prot :

  Q8TDX6

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human CSGALNACT1. AA range:201-250

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  60kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  60kD

• Fragment :

  IgG

• Subcellular Location :

  Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein .

• Other Product Names :

  CSGALNACT1; CHGN; GALNACT1; Chondroitin sulfate N-acetylgalactosaminyltransferase 1; CsGalNAcT-1; Chondroitin beta-1; 4-N-acetylgalactosaminyltransferase 1; Beta4GalNAcT-1

• Gene ID (Human) :

  55790