Nicalin rabbit pAb

• Background :

  Function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning., similarity:Belongs to the nicastrin family., subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex., tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.

• Description :

  Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. similarity: Belongs to the nicastrin family. subunit: Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.

• UniProt :

  Q969V3

• Swiss Prot :

  Q969V3

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human NCLN. AA range:474-523

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  63kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  63kD

• Fragment :

  IgG

• Subcellular Location :

  Endoplasmic reticulum membrane ; Single-pass membrane protein .

• Other Product Names :

  NCLN; Nicalin; Nicastrin-like protein

• Gene ID (Human) :

  56926