Claudin-5 (phospho Tyr217) rabbit pAb

• Background :

  This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]

• Description :

  This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008],

• UniProt :

  O00501

• Swiss Prot :

  O00501

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human Claudin 5 around the phosphorylation site of Tyr217. AA range:169-218

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF; WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight :

  23kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  23kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.

• Other Product Names :

  CLDN5; AWAL; TMVCF; Claudin-5; Transmembrane protein deleted in VCFS; TMDVCF

• Gene ID (Human) :

  7122