VCP rabbit pAb

• Background :

  Valosin containing protein (VCP) Homo sapiens The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]

• Description :

  Valosin containing protein (VCP) Homo sapiens The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008],

• UniProt :

  P55072

• Swiss Prot :

  P55072

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human VCP. AA range:318-367

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  85kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  85kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytosol . Endoplasmic reticulum . Nucleus . Cytoplasm, Stress granule . Present in the neuronal hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients (PubMed:15456787) . Present in the Lewy bodies specifically found in neurons from Parkinson disease patients (PubMed:15456787) . Recruited to the cytoplasmic surface of the endoplasmic reticulum via interaction with AMFR/gp78 (PubMed:16168377) . Following DNA double-strand breaks, recruited to the sites of damage (PubMed:22120668) . Recruited to stalled replication forks via interaction with SPRTN (PubMed:23042605) . Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622) . Colocalizes with TIA1, ZFAND1 and G3BP1 in cytoplasmic stress granules (SGs) in

• Other Product Names :

  VCP; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg (2+) -ATPase p97 subunit; Valosin-containing protein; VCP

• Gene ID (Human) :

  7415