CD6 rabbit pAb

• Background :

  This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

• Description :

  This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

• Product Name Alternative :

  CD6; T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6

• UniProt :

  P30203

• Swiss Prot :

  P30203

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human CD6. AA range:250-299

• Target :

  CD6

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  73kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  73kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein . Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806) . Colocalizes with the TCR/CD3 complex at the immunological synapse (PubMed:15294938) . .; [Soluble CD6]: Secreted . The origins of the secreted form are not clear, but it might be created by proteolytic shedding of the ectodomain. .

• Other Product Names :

  CD6; T-cell differentiation antigen CD6; T12; TP120; CD antigen CD6

• Gene ID (Human) :

  923