ZO-2 rabbit pAb

• Background :

  This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Description :

  This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

• Product Name Alternative :

  TJP2; X104; ZO2; Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2

• UniProt :

  Q9UDY2

• Swiss Prot :

  Q9UDY2

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human ZO-2. AA range:1063-1112

• Target :

  ZO-2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  160kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  160kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, adherens junction. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, tight junction . Nucleus . Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. .

• Other Product Names :

  TJP2; X104; ZO2; Tight junction protein ZO-2; Tight junction protein 2; Zona occludens protein 2; Zonula occludens protein 2

• Gene ID (Human) :

  9414