GRP78 BiP rabbit pAb

• Background :

  The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

• Description :

  The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell. [provided by RefSeq, Sep 2010],

• Product Name Alternative :

  78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)

• UniProt :

  P11021

• Swiss Prot :

  P11021

• Reactivity :

  Human; Mouse; Rat; Fish

• Immunogen :

  Synthetic peptide from human protein at AA range: 505-570

• Target :

  HSP A5/GRP78

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000.IHC-p/f:1:50-300. ELISA 1:10000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  78kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  78kD

• Fragment :

  IgG

• Subcellular Location :

  Endoplasmic reticulum lumen . Melanosome . Cytoplasm . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545) . Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390) . .

• Other Product Names :

  78 kDa glucose-regulated protein (GRP-78) (Endoplasmic reticulum lumenal Ca (2+) -binding protein grp78) (Heat shock 70 kDa protein 5) (Immunoglobulin heavy chain-binding protein) (BiP)

• Gene ID (Human) :

  3309