GLI-1 rabbit pAb

• Background :

  This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

• Description :

  This gene encodes a member of the Kruppel family of Zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],

• UniProt :

  P08151

• Swiss Prot :

  P08151

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human GLI-1. at AA range: 460-490

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000, ELISA 1:10000-20000

• Molecular Weight :

  120kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  120kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Tethered in the cytoplasm by binding to SUFU (PubMed:10806483) . Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483) . Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745) . Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441) . .; [Isoform 2]: Cytoplasm . Nucleus .

• Other Product Names :

  Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI)

• Gene ID (Human) :

  2735