ANR28 rabbit pAb

• Background :

  Function:Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation., similarity:Contains 27 ANK repeats., subcellular location:Seems to be excluded from nucleoli., subunit:Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS) . Interacts with PPP1C and HNRPK. Interacts with PPP6C, SAPS1 and SAPS3.

• Description :

  Function: Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. similarity: Contains 27 ANK repeats. subcellular location: Seems to be excluded from nucleoli. subunit: Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, SAPS1 and SAPS3.

• UniProt :

  O15084

• Swiss Prot :

  O15084

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 980-1060

• Target :

  ANR28

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  115kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  115kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, nucleoplasm . Seems to be excluded from nucleoli.

• Gene ID (Human) :

  23243