DNA2 rabbit pAb

• Background :

  This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

• Description :

  This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],

• UniProt :

  P51530

• Swiss Prot :

  P51530

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  116kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  116kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus. Mitochondrion. Was initially reported to be exclusively mitochondrial (PubMed:18995831) . However, it was later shown to localize both in mitochondrion and nucleus (PubMed:19487465) . .

• Gene ID (Human) :

  1763