PR40A rabbit pAb

• Background :

  Domain:The WW domains are essential for localization to nuclear speckles., function:Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity) . May be involved in pre-mRNA splicing., sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 409., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the PRPF40 family., similarity:Contains 2 WW domains., similarity:Contains 5 FF domains., subunit:Interacts with the N-terminus of HTT. Interacts with the phosphorylated carboxyterminal domain of POLR2A. Interacts with SF1, SRPK1 CARD8, ATBF1 and MECP2 (By similarity) . Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP., tissue specificity:Widely expressed.

• Description :

  Domain: The WW domains are essential for localization to nuclear speckles. function: Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). May be involved in pre-mRNA splicing. sequence Caution: Contaminating sequence. Potential poly-A sequence starting in position 409. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the PRPF40 family. similarity: Contains 2 WW domains. similarity: Contains 5 FF domains. subunit: Interacts with the N-terminus of HTT. Interacts with the phosphorylated carboxyterminal domain of POLR2A. Interacts with SF1, SRPK1 CARD8, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP. tissue specificity: Widely expressed.

• UniProt :

  O75400

• Swiss Prot :

  O75400

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 450-530

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  105kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  105kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus speckle . Nucleus matrix . Colocalizes with AKAP8L in the nuclear matrix. .

• Gene ID (Human) :

  55660