3BP1 rabbit pAb

• Background :

  Function:Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac., sequence caution:Translated as Cys., similarity:Contains 1 BAR domain., similarity:Contains 1 Rho-GAP domain.

• Description :

  Function: Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac. sequence Caution: Translated as Cys. similarity: Contains 1 BAR domain. similarity: Contains 1 Rho-GAP domain.

• UniProt :

  Q9Y3L3

• Swiss Prot :

  Q9Y3L3

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 170-250

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  77kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  77kD

• Fragment :

  IgG

• Subcellular Location :

  Cell projection . Cell junction, tight junction . Cell junction, adherens junction . Cell projection, phagocytic cup . Nucleus . Cytoplasm, cytosol . Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563) . Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210) . .

• Gene ID (Human) :

  23616