PTN2 rabbit pAb

• Background :

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

• Description :

  The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011],

• UniProt :

  P17706

• Swiss Prot :

  P17706

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  PTN2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  45kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  45kD

• Fragment :

  IgG

• Subcellular Location :

  [Isoform 1]: Endoplasmic reticulum . Endoplasmic reticulum-Golgi intermediate compartment . Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. .; [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Predominantly localizes to chromatin (By similarity) . Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479) . Recruited by activated ITGA1 at the plasma membrane. .

• Gene ID (Human) :

  5771