UBP6 rabbit pAb

• Background :

  Catalytic activity:Ubiquitin C-terminal thioester + H (2) O = ubiquitin + a thiol., disease:Involved in tumorigenesis., function:Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity., miscellaneous:The USP6 gene only exists in the primate lineage., similarity:Belongs to the peptidase C19 family., similarity:Contains 1 Rab-GAP TBC domain., tissue specificity:Testis specific. Expressed in various cancer cell lines.

• Description :

  Catalytic activity: Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol. Disease: Involved in tumorigenesis. function: Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. miscellaneous: The USP6 gene only exists in the primate lineage. similarity: Belongs to the peptidase C19 family. similarity: Contains 1 Rab-GAP TBC domain. tissue specificity: Testis specific. Expressed in various cancer cell lines.

• UniProt :

  P35125

• Swiss Prot :

  P35125

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  154kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  154kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane. Cytoplasm. Endosome. Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.

• Gene ID (Human) :

  9098