MUL1 rabbit pAb

• Background :

  Domain:The zinc finger domain is required for E3 ligase activity., function:E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 RING-type zinc finger., subcellular location:Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome., subunit:Homooligomer. Interacts with MAP3K7/TAK1., tissue specificity:Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.

• Description :

  Domain: The zinc finger domain is required for E3 ligase activity. function: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 RING-type zinc finger. subcellular location: Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. subunit: Homooligomer. Interacts with MAP3K7/TAK1. tissue specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.

• UniProt :

  Q969V5

• Swiss Prot :

  Q969V5

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  MUL1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  38kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  38kD

• Fragment :

  IgG

• Subcellular Location :

  Mitochondrion outer membrane ; Multi-pass membrane protein . Peroxisome . Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. .

• Gene ID (Human) :

  79594