IRGM rabbit pAb

• Background :

  Immunity related GTPase M (IRGM) Homo sapiens This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]

• Description :

  Immunity related GTPase M (IRGM) Homo sapiens This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. [provided by RefSeq, Oct 2010],

• UniProt :

  A1A4Y4

• Swiss Prot :

  A1A4Y4

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 101-150

• Target :

  IRGM

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  19kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  19kD

• Fragment :

  IgG

• Subcellular Location :

  Golgi apparatus membrane . Cell membrane . Cytoplasmic vesicle, phagosome membrane . Cytoplasmic vesicle, autophagosome membrane . Cell projection, phagocytic cup . Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. .

• Gene ID (Human) :

  345611