MRGX2 rabbit pAb

• Background :

  Function:Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q) -coupled., similarity:Belongs to the G-protein coupled receptor 1 family. Mas subfamily., tissue specificity:Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

• Description :

  Function: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca (2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G (q)-coupled. similarity: Belongs to the G-protein coupled receptor 1 family. Mas subfamily. tissue specificity: Has a limited expression profile, both peripheral and within the central nervous system, with highest levels in dorsal root ganglion.

• UniProt :

  Q96LB1

• Swiss Prot :

  Q96LB1

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human protein . at AA range: 250-330

• Target :

  MRGX2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  36kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  36kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane; Multi-pass membrane protein .

• Gene ID (Human) :

  117194