ELAV1 rabbit pAb

• Background :

  ELAV like RNA binding protein 1 (ELAVL1) Homo sapiens The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]

• Description :

  ELAV like RNA binding protein 1 (ELAVL1) Homo sapiens The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012],

• UniProt :

  Q15717

• Swiss Prot :

  Q15717

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  ELAV1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  35kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  35kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Cytoplasm, Stress granule . Cytoplasm, P-body . Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288) . Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462) .Localizes to the stress granules in the presence of PLEKHN1 (By similarity) . .

• Gene ID (Human) :

  1994