53BP1 (phospho-Thr543) rabbit pAb

• UniProt :

  Q12888

• Swiss Prot :

  Q12888

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized phosho peptide around human 53BP1 (Thr543)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000

• Molecular Weight :

  213kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  213kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Chromosome . Chromosome, centromere, kinetochore . Localizes to the nucleus in absence of DNA damage (PubMed:28241136) . Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs) : recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600) . Associated with kinetochores during mitosis (By similarity) . .

• Other Product Names :

  Tumor suppressor p53-binding protein 1 (53BP1) (p53-binding protein 1) (p53BP1)

• Gene ID (Human) :

  7158