DNA pol β (Acetyl Lys72) rabbit pAb

• Background :

  Catalytic activity:Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1) ., cofactor:Binds 2 magnesium ions per subunit., domain:Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity., function:Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., PTM:Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity., similarity:Belongs to the DNA polymerase type-X family., subunit:Monomer.

• Description :

  Catalytic activity: Deoxynucleoside triphosphate + DNA (n) = diphosphate + DNA (n+1). Cofactor: Binds 2 magnesium ions per subunit. Domain: Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity. function: Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. PTM: Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity. similarity: Belongs to the DNA polymerase type-X family. subunit: Monomer.

• UniProt :

  P06746

• Swiss Prot :

  P06746

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human DNA pol β (Acetyl Lys72)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  38kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  38kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus. Cytoplasm. Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.

• Other Product Names :

  DNA polymerase beta (EC 2.7.7.7; EC 4.2.99.-)

• Gene ID (Human) :

  5423