MMP8 (Cleaved-Leu101) rabbit pAb

• Background :

  Catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 3 calcium ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Cannot be activated without removal of the activation peptide., function:Can degrade fibrillar type I, II, and III collagens., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., subcellular location:Stored in intracellular granules., tissue specificity:Neutrophils.

• Description :

  Catalytic activity: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3. 4. 24. 7, this enzyme cleaves type III collagen more slowly than type I. Cofactor: Binds 2 zinc ions per subunit. Cofactor: Binds 3 calcium ions per subunit. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. enzyme regulation: Cannot be activated without removal of the activation peptide. function: Can degrade fibrillar type I, II, and III collagens. similarity: Belongs to the peptidase M10A family. similarity: Contains 4 hemopexin-like domains. subcellular location: Stored in intracellular granules. tissue specificity: Neutrophils.

• UniProt :

  P22894

• Swiss Prot :

  P22894

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human MMP8 (Cleaved-Leu101)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight :

  40 53kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  40 53kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasmic granule. Secreted, extracellular space, extracellular matrix . Stored in intracellular granules.

• Other Product Names :

  Neutrophil collagenase (EC 3.4.24.34; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL)

• Gene ID (Human) :

  4317