IL1RA rabbit pAb

• Background :

  Disease:Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM:612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4) . Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function., function:Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity., online information:Interleukin-1 entry, online information:The Singapore human mutation and polymorphism database, pharmaceutical:Available under the name Kineret (Amgen) . Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis., similarity:Belongs to the IL-1 family., tissue specificity:The intracellular form of IL1RN is predominantly expressed in epithelial cells.

• Description :

  Disease: Genetic variation in IL1RN is associated with susceptibility to diabetic nephropathy [MIM: 612628]; also called susceptibility to microvascular complications of diabetes type 4 (MVCD4). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function. function: Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity. online information: Interleukin-1 entry, online information: The Singapore human mutation and polymorphism database, pharmaceutical: Available under the name Kineret (Amgen). Used for the reduction in signs and symptoms and slowing the progression of structural damage in moderately to severely active rheumatoid arthritis. similarity: Belongs to the IL-1 family. tissue specificity: The intracellular form of IL1RN is predominantly expressed in epithelial cells.

• UniProt :

  P18510

• Swiss Prot :

  P18510

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human IL1RA

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  [Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm.

• Other Product Names :

  Interleukin-1 receptor antagonist protein (IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 inhibitor; Anakinra)

• Gene ID (Human) :

  3557