P21 (Acetyl Lys161/K163) rabbit pAb

• Background :

  Function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression., induction:By p53, mezerein (antileukemic compound) and interferon beta., PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA., similarity:Belongs to the CDI family., tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.

• Description :

  Function: May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. induction: By p53, mezerein (antileukemic compound) and interferon beta. PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA. similarity: Belongs to the CDI family. tissue specificity: Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.

• UniProt :

  P38936

• Swiss Prot :

  P38936

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human p21 (Acetyl Lys161/K163)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  21kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  21kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus .

• Other Product Names :

  Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21)

• Gene ID (Human) :

  1026