AMPKβ2 rabbit pAb

• Background :

  The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]

• Description :

  The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],

• Product Name Alternative :

  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

• UniProt :

  O43741

• Swiss Prot :

  O43741

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant Protein of AMPKβ2

• Target :

  AMPKβ2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Dilution :

  WB: 1:1000-2000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  30kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  30kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleoplasm, cytosol, nucleotide-activated protein kinase complex

• Other Product Names :

  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2; AMPK subunit beta-2

• Gene ID (Human) :

  5565