WBS22 rabbit pAb

• Background :

  This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011]

• Description :

  This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11. 23. Alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2011],

• UniProt :

  O43709

• Swiss Prot :

  O43709

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human WBS22 AA range: 144-194

• Target :

  WBS22

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000

• Buffer :

  -20°C/1 year

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Nucleus, nucleoplasm . Cytoplasm, perinuclear region . Cytoplasm . Localized diffusely throughout the nucleus and the cytoplasm (PubMed:24488492) . Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604) . Localization is not affected by glucocorticoid treatment (PubMed:24488492) . .

• Gene ID (Human) :

  114049