MMP7 (Cleaved-Tyr95) rabbit pAb

• Background :

  Catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2 (I) > alpha-1 (I) ., cofactor:Binds 2 calcium ions per subunit., cofactor:Binds 2 zinc ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., function:Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase., similarity:Belongs to the peptidase M10A family.

• Description :

  Catalytic activity: Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2 (I) > alpha-1 (I). Cofactor: Binds 2 calcium ions per subunit. Cofactor: Binds 2 zinc ions per subunit. Domain: The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. function: Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. similarity: Belongs to the peptidase M10A family.

• UniProt :

  P09237

• Swiss Prot :

  P09237

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human MMP7 (Cleaved-Tyr95)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  19 29kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  19 29kD

• Fragment :

  IgG

• Subcellular Location :

  Secreted, extracellular space, extracellular matrix .

• Other Product Names :

  Matrilysin (EC 3.4.24.23; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase)

• Gene ID (Human) :

  4316