PDLI2 rabbit pAb

• Background :

  This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

• Description :

  This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],

• Product Name Alternative :

  PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)

• UniProt :

  Q96JY6

• Swiss Prot :

  Q96JY6

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human PDLI2 AA range: 190-240

• Target :

  PDLI2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  38kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  38kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) .; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.

• Other Product Names :

  PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)

• Gene ID (Human) :

  64236