FA10 (light chain, Cleaved-Arg179) rabbit pAb

• Background :

  Catalytic activity:Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin., function:Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting., online information:Factor X entry, PTM:N- and O-glycosylated., PTM:The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway) ., PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains., PTM:The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium., similarity:Belongs to the peptidase S1 family., similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain., similarity:Contains 1 peptidase S1 domain., similarity:Contains 2 EGF-like domains., subunit:The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds., tissue specificity:Plasma; synthesized in the liver.

• Description :

  Catalytic activity: Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin. function: Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. online information: Factor X entry, PTM: N- and O-glycosylated. PTM: The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. PTM: The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. similarity: Belongs to the peptidase S1 family. similarity: Contains 1 Gla (gamma-carboxy-glutamate) domain. similarity: Contains 1 peptidase S1 domain. similarity: Contains 2 EGF-like domains. subunit: The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. tissue specificity: Plasma; synthesized in the liver.

• UniProt :

  P00742

• Swiss Prot :

  P00742

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human FA10 (light chain, Cleaved-Arg179)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  15 53kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  15 53kD

• Fragment :

  IgG

• Subcellular Location :

  Secreted.

• Other Product Names :

  Coagulation factor X (EC 3.4.21.6; Stuart factor; Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]

• Gene ID (Human) :

  2159