ITGAV (light chain, Cleaved-Asp891) rabbit pAb

• Background :

  Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]

• Description :

  Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],

• UniProt :

  P06756

• Swiss Prot :

  P06756

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  17 110kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  17 110kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion .

• Other Product Names :

  Integrin alpha-V (Vitronectin receptor subunit alpha; CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]

• Gene ID (Human) :

  3685