CATL1 (heavy chain, Cleaved-Ala114) rabbit pAb

• Background :

  Catalytic activity:Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity., function:Important for the overall degradation of proteins in lysosomes., similarity:Belongs to the peptidase C1 family., subunit:Dimer of a heavy and a light chain linked by disulfide bonds.

• Description :

  Catalytic activity: Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. function: Important for the overall degradation of proteins in lysosomes. similarity: Belongs to the peptidase C1 family. subunit: Dimer of a heavy and a light chain linked by disulfide bonds.

• UniProt :

  P07711

• Swiss Prot :

  P07711

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human CATL1 (heavy chain, Cleaved-Ala114)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  25 37kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  25 37kD

• Fragment :

  IgG

• Subcellular Location :

  Lysosome . Apical cell membrane ; Peripheral membrane protein ; Extracellular side . Cytoplasmic vesicle, secretory vesicle, chromaffin granule . Secreted, extracellular space . Secreted . Localizes to the apical membrane of thyroid epithelial cells. Released at extracellular space by activated dendritic cells and macrophages. .; [Isoform 2]: Nucleus . Translation initiation at downstream start sites allows the synthesis of isoforms that are devoid of a signal peptide and do not transit through the endoplasmic reticulum to localize to the nucleus (PubMed:15099520) . Nuclear location varies during the cell cycle, with higher levels during S phase (PubMed:15099520) . .

• Other Product Names :

  Cathepsin L1 (EC 3.4.22.15; Major excreted protein; MEP) [Cleaved into: Cathepsin L1 heavy chain; Cathepsin L1 light chain]

• Gene ID (Human) :

  1514