ATG13 Rabbit pAb

• Background :

  Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.

• Description :

  Atg13 was identified as a constitutively expressed protein that was genetically linked to Atg1/Apg1, a protein kinase required for autophagy. Overexpression of Atg1 suppresses the defects in autophagy observed in Atg13 mutants. Autophagy requires a direct association between Atg1 and Atg13, and is inhibited by TOR-dependent phosphorylation of Atg13 under high-nutrient conditions.

• Product Name Alternative :

  Autophagy-related protein 13

• UniProt :

  O75143

• Swiss Prot :

  O75143

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human ATG13 AA range: 182-232

• Target :

  ATG13

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; WB

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p1:50-200 , WB 1:1000-2000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  72kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  72kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. .

• Other Product Names :

  Autophagy-related protein 13

• Gene ID (Human) :

  9776