ERK 5 rabbit pAb

• Background :

  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5) . It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

• Description :

  The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008],

• UniProt :

  Q13164

• Swiss Prot :

  Q13164

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant Protein of ERK 5

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF

• Dilution :

  WB: 1:1000-2000 IHC:1:200-500

• Molecular Weight :

  89-115kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  89-115kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm. Nucleus. Nucleus, PML body. Translocates to the nucleus upon activation.

• Other Product Names :

  MAPK7; BMK1; ERK5; PRKM7; Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1; BMK-1; Extracellular signal-regulated kinase 5; ERK-5

• Gene ID (Human) :

  5598