JAK1 (phospho Tyr1022) rabbit pAb

• Background :

  This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• Description :

  This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

• UniProt :

  P23458

• Swiss Prot :

  P23458

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1022. AA range:988-1037

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IF; WB; IP; IHC; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight :

  132kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  132kD

• Fragment :

  IgG

• Subcellular Location :

  Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.

• Other Product Names :

  JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1

• Gene ID (Human) :

  3716